pulmoCORE Panel 2 (EGFR (RT PCR), ALK (FISH), ROS-1 (FISH)) is a set of tests that detects genetic changes (mutations) in two different genes namely epidermal growth factor receptor (EGFR) gene and ROS-1 (Repressor of Silencing 1) gene. This panel also identif...
DiagnosticsHealth package
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pulmoCORE Panel 2 (EGFR (RT PCR), ALK (FISH), ROS-1 (FISH)) is a set of tests that detects genetic changes (mutations) in two different genes namely epidermal growth factor receptor (EGFR) gene and ROS-1 (Repressor of Silencing 1) gene. This panel al...
Understanding Pulmocore Panel 2
pulmoCORE Panel 2 (EGFR (RT PCR), ALK (FISH), ROS-1 (FISH)) is a set of tests that detects genetic changes (mutations) in two different genes namely epidermal growth factor receptor (EGFR) gene and ROS-1 (Repressor of Silencing 1) gene. This panel also identifies anaplastic lymphoma kinase (ALK) gene rearrangement on chromosome 2. Any mutations in EGFR and ROS-1 genes can lead to non-small cell lung carcinoma (NSCLC), the most common form of lung cancer. Gene rearrangements involving the ALK gene are present in app...
What does Pulmocore Panel 2 measure?
Contains 3 tests
Pulmocore Panel 2 includes ROS-1 by FISH, EGFR (RTPCR), ALK by FISH.
Package contains 3 tests
Showing 3 of 3 tests
ROS-1 by FISH is a test used to detect genetic changes (mutations) in the ROS-1 (Repressor of Silencing 1) gene which is responsible for cell growth and development. The ROS1 gene located on chromosome 6 has the potential to undergo fusion or rearrangement, leading to the development of uncontrolled cell growth and the onset of non-small cell lung cancer (NSCLC), the most common form of lung cancer. A FISH technique is used to screen for these fusions. Gene fusions involving ROS1 are present in 1-2% of non-small cell lung carcinoma (NSCLC). Patients with ROS1-fusion-positive tumors have shown good responses to Kinase inhibitors or Crizotinib therapy.
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