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Microsatellite Instability (MSI)
The Microsatellite Instability (MSI) detects genetic changes in specific repetitive DNA sequences within tumor cells. These changes occur when the DNA mismatch repair (MMR) system fails to work properly. The test helps identify conditions such as Lynch syndrom...
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The Microsatellite Instability (MSI) detects genetic changes in specific repetitive DNA sequences within tumor cells. These changes occur when the DNA mismatch repair (MMR) system fails to work properly. The test helps identify conditions such as Lyn...
Understanding Microsatellite Instability (MSI)
The Microsatellite Instability (MSI) test is a molecular diagnostic test that evaluates the stability of short, repetitive DNA sequences known as microsatellites. Normally, the body’s DNA mismatch repair (MMR) system corrects any errors that occur during DNA replication. However, if there are mutations or defects in the MMR genes, these errors accumulate, leading to microsatellite instability (MSI).
This instability is often associated with Lynch syndrome (Hereditary Non-Polyposis Colorectal Cancer or HNPCC)...
What does Microsatellite Instability (MSI) measure?
The Microsatellite Instability (MSI) detects genetic changes in specific repetitive DNA sequences within tumor cells. These changes occur when the DNA mismatch repair (MMR) system fails to work properly. The test helps identify conditions such as Lynch syndrome (Hereditary Non-Polyposis Colorectal Cancer) and guides treatment decisions.
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